氨基酸
残留物(化学)
氨基酸残基
蛋白质进化
化学
生物化学
立体化学
肽序列
基因
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1974-09-06
卷期号:185 (4154): 862-864
被引量:2137
标识
DOI:10.1126/science.185.4154.862
摘要
A formula for diference between amino acids combines properties that correlate best with protein residue substitution frequencies: composition, polarity, and molecular volume. Substitution frequencies agree much better with overall chemical difference between exchanging residues than with minimum base changes between their codons. Correlation coefficients show that fixation of mutations between dissimilar amino acids is generally rare.
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