生长素
肥胖
瘦素
超重
医学
公共卫生
生物信息学
人类肥胖
神经科学
生物
内分泌学
激素
病理
作者
David Cummings,Michael W. Schwartz
出处
期刊:Annual Review of Medicine
[Annual Reviews]
日期:2003-02-01
卷期号:54 (1): 453-471
被引量:377
标识
DOI:10.1146/annurev.med.54.101601.152403
摘要
Obesity has become a leading public health concern. Over 1 billion people are now overweight or obese, and the prevalence of these conditions is rising rapidly. Remarkable new insights into the mechanisms that control body weight are providing an increasingly detailed framework for a better understanding of obesity pathogenesis. Key peripheral signals, such as leptin, insulin, and ghrelin, have been linked to hypothalamic neuropeptide systems, and the anatomic and functional networks that integrate these systems have begun to be elucidated. This article highlights some of these recent findings and their implications for the future of obesity treatment. “Banish plump Jack, and banish all the world.” William Shakespeare, King Henry IV Part 1
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