DNA损伤
DNA修复
DNA
生物
遗传学
计算生物学
作者
Narendra Tuteja,Mohan B. Singh,Mithilesh K. Misra,Prem L. Bhalla,Renu Tuteja
标识
DOI:10.1080/20014091074219
摘要
Dedicated to Prof. Jan H. J. Hoeijmakers.Referee: Dr. Nawin C. Mishra, Professor of Genetics, University of South Carolina, Department of Biological Sciences, Columbia, SC 29208Despite stable genomes of all living organisms, they are subject to damage by chemical and physical agents in the environment (e.g., UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. The DNA lesions produced by these damaging agents could be altered base, missing base, mismatch base, deletion or insertion, linked pyrimidines, strand breaks, intra- and inter-strand cross-links.
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