Opportunities and Challenges for the Nasal Administration of Nanoemulsions

鼻腔给药 生物利用度 鼻粘膜 鼻子 医学 佐剂 药物输送 免疫系统 药理学 药品 吸收(声学) 给药途径 免疫学 纳米技术 外科 材料科学 复合材料
作者
Claurice Comfort,Gabriela Garrastazu Pereira,Michele Pozzoli,Fabio Sonvico
出处
期刊:Current Topics in Medicinal Chemistry [Bentham Science Publishers]
卷期号:15 (4): 356-368 被引量:65
标识
DOI:10.2174/1568026615666150108144655
摘要

Nasal delivery has become a growing area of interest for drug administration as a consequence of several practical advantages, such as ease of administration and non-invasiveness. Moreover, the avoidance of hepatic first-pass metabolism and rapid and efficient absorption across the permeable nasal mucosa offer a promising alternative to other traditional administration routes, such as oral or parenteral delivery. In fact, nasal delivery has been proposed for a number of applications, including local, systemic, direct nose-to-brain and mucosal vaccine delivery. Nanoemulsions, due to their stability, small droplet size and optimal solubilization properties, represent a versatile formulation approach suitable for several administration routes. Nanoemulsions demonstrated great potential in nasal drug delivery, increasing the absorption and the bioavailability of many drugs for systemic and nose-tobrain delivery. Furthermore, they act as an active component, i.e. an adjuvant, in nasal mucosal vaccinations, displaying the ability to induce robust mucosal immunity, high serum antibodies titres and a cellular immune response avoiding inflammatory response. Interestingly, nanoemulsions have not been proposed for the treatment of local ailments of the nose. Despite the promising results in vitro and in vitro, the application of nanoemulsions for nasal delivery in humans appears mainly hindered by the lack of detailed toxicology studies to determine the effect of these formulations on the nasal mucosa and cilia and the lack of extensive clinical trials. Keywords: Drug delivery, Mucosal vaccine, Nanoemulsions, Nasal delivery, Nose to brain, Pharmaceutical nanotechnology.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
科研通AI2S应助Kris采纳,获得10
2秒前
3秒前
彭于晏应助儒雅的梦芝采纳,获得10
4秒前
CodeCraft应助哈利波特采纳,获得10
5秒前
李爱国应助唐Doctor采纳,获得10
7秒前
8秒前
8秒前
9秒前
10秒前
anna发布了新的文献求助10
10秒前
12秒前
13秒前
杪杪发布了新的文献求助10
13秒前
15秒前
hua发布了新的文献求助10
15秒前
小仙丹完成签到,获得积分20
15秒前
16秒前
锦城纯契完成签到 ,获得积分10
16秒前
feng1235发布了新的文献求助20
17秒前
gxzsdf完成签到 ,获得积分10
18秒前
GGBOND发布了新的文献求助10
18秒前
知性的剑身完成签到,获得积分10
18秒前
Dalia完成签到,获得积分10
19秒前
量子星尘发布了新的文献求助10
19秒前
萨日呼发布了新的文献求助10
21秒前
史念薇完成签到,获得积分10
22秒前
传奇3应助晓晓采纳,获得10
24秒前
27秒前
细腻涛完成签到,获得积分10
31秒前
31秒前
儒雅的梦芝完成签到,获得积分10
32秒前
Rondab应助科研达人采纳,获得30
33秒前
何白完成签到,获得积分10
33秒前
34秒前
哈利波特发布了新的文献求助10
35秒前
qsy完成签到,获得积分10
35秒前
共享精神应助chun采纳,获得10
36秒前
小马甲应助mr.pork采纳,获得10
36秒前
清新的小懒猪完成签到,获得积分10
37秒前
酷波er应助科研通管家采纳,获得10
37秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989115
求助须知:如何正确求助?哪些是违规求助? 3531367
关于积分的说明 11253688
捐赠科研通 3269986
什么是DOI,文献DOI怎么找? 1804868
邀请新用户注册赠送积分活动 882078
科研通“疑难数据库(出版商)”最低求助积分说明 809105