Effects of bezafibrate in nonalcoholic steatohepatitis model mice with monosodium glutamate-induced metabolic syndrome

贝扎纤维 内分泌学 内科学 医学 味精 脂肪肝 高脂血症 糖尿病 脂肪组织 脂肪性肝炎 脂肪变性 瘦素 肥胖 疾病
作者
Yoshiyuki Sasaki,Tsutomu Shimada,Seiichi Iizuka,Wataru Suzuki,Hiroko Makihara,Ryutaro Teraoka,Koichi Tsuneyama,Ryoji Hokao,Masaki Aburada
出处
期刊:European Journal of Pharmacology [Elsevier]
卷期号:662 (1-3): 1-8 被引量:36
标识
DOI:10.1016/j.ejphar.2011.04.051
摘要

Recently, we reported that monosodium glutamate-treated mice (MSG mice) developed severe hyperlipidemia and diabetes mellitus and several complications of obesity. MSG mice acquired fatty livers and subsequently underwent changes that are characteristic of nonalcoholic fatty liver disease (NAFLD)/nonalcoholic steatohepatitis (NASH). In the present study, the effects of bezafibrate on obesity, diabetes mellitus, and NAFLD/NASH were examined in MSG mice. A single dose of MSG (4 mg/g) was administered subcutaneously to neonatal male mice within 24h of birth. Bezafibrate was mixed into the normal feed for 8 weeks. The weight and body mass index of MSG mice increased significantly despite the unchanged intake of food. Triglyceride and total cholesterol levels in blood, visceral adipose tissue, and interscapular adipose tissue rose significantly. In the livers of MSG mice, moderate centrilobular microvesicular steatosis, ballooning degeneration with Mallory bodies, and scattered infiltration of neutrophils and lymphocytes were observed. Centrilobular hepatocytes were 4-hydroxynonenal-positive in MSG mice. Bezafibrate ameliorated the severity of diabetes mellitus, hyperinsulinemia, and hyperlipidemia. Adiponectin and leptin concentrations in blood improved, and the accumulation of visceral fat was inhibited. The expression of acyl-CoA oxidase, a beta-oxidation gene, and carnitine palmitoyl transferase, which regulates lipid metabolism, increased markedly on administration of bezafibrate. The liver pathology in MSG mice also improved with bezafibrate; specifically, macro- and microvesicles in hepatocytes nearly disappeared, and NAFLD activity score improved. It is concluded that bezafibrate inhibits the accumulation of visceral fat, following amelioration of hyperlipidemia, in MSG-induced obese mice, due to improvements in diabetes mellitus, fatty liver, and NAFLD.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
CodeCraft应助爱笑的大白菜采纳,获得10
1秒前
1秒前
1秒前
vanilla完成签到,获得积分10
2秒前
陈博士完成签到,获得积分10
3秒前
Emily完成签到,获得积分10
3秒前
马东完成签到,获得积分10
6秒前
在水一方应助qiiq1997采纳,获得10
6秒前
bluefire完成签到,获得积分10
7秒前
7秒前
vetXue发布了新的文献求助10
7秒前
Erick爱喝粥完成签到,获得积分10
8秒前
机智依丝发布了新的文献求助10
8秒前
9秒前
小小王发布了新的文献求助10
9秒前
10秒前
英俊的铭应助慕辰采纳,获得10
12秒前
啦啦啦发布了新的文献求助10
13秒前
zrz完成签到,获得积分10
13秒前
14秒前
14秒前
ahaaa发布了新的文献求助10
15秒前
15秒前
天天快乐应助激情的一斩采纳,获得10
15秒前
欢喜的代容完成签到,获得积分10
16秒前
隐形之玉完成签到,获得积分10
16秒前
17秒前
NexusExplorer应助mml采纳,获得10
17秒前
lhy完成签到,获得积分10
18秒前
五香完成签到 ,获得积分10
18秒前
樂事发布了新的文献求助10
20秒前
21秒前
xingzou完成签到,获得积分10
21秒前
21秒前
濮阳冰海完成签到 ,获得积分10
21秒前
21秒前
22秒前
烟花应助jjb采纳,获得10
23秒前
苦力怕发布了新的文献求助10
23秒前
Fan完成签到,获得积分10
23秒前
高分求助中
Sustainability in Tides Chemistry 2800
Kinetics of the Esterification Between 2-[(4-hydroxybutoxy)carbonyl] Benzoic Acid with 1,4-Butanediol: Tetrabutyl Orthotitanate as Catalyst 1000
The Young builders of New china : the visit of the delegation of the WFDY to the Chinese People's Republic 1000
Rechtsphilosophie 1000
Bayesian Models of Cognition:Reverse Engineering the Mind 888
Handbook of Qualitative Cross-Cultural Research Methods 600
Very-high-order BVD Schemes Using β-variable THINC Method 568
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3137423
求助须知:如何正确求助?哪些是违规求助? 2788470
关于积分的说明 7786719
捐赠科研通 2444666
什么是DOI,文献DOI怎么找? 1300018
科研通“疑难数据库(出版商)”最低求助积分说明 625731
版权声明 601023