Synthesis and DNA Binding Affinity of Some New 7-Hydroxy-3-Carbaldehyde Chromones

Two novel ligands, 7-methoxy chromone-3-carbaldehyde-salicylyl hydrazone and 7-hydroxy chromone-3-carbaldehyde-salicylyl hydrazone, were prepared by resorcinol. Their respective Eu (III) complexes had been synthesized and characterized on the base of elemental analyses, molar conductivities, IR spectra, mass spectra, UV-Vis spectra, and fluorescence studies. The interactions of the Eu (III) complexes and their ligands with calf-thymus DNA were investigated, which were found that both two ligands and their rare earth complexes could strongly bind with calf-thymus DNA via an intercalation mechanism.