失智症
神经科学
刺激
默认模式网络
功能连接
心理学
认知
脑刺激
痴呆
阿尔茨海默病
医学
疾病
内科学
作者
Lorenzo Pini,Francesca B. Pizzini,Ilaria Boscolo Galazzo,Clarissa Ferrari,Samantha Galluzzi,Maria Cotelli,Elena Gobbi,Annamaria Cattaneo,Maria Sofia Cotelli,Cristina Geroldi,Orazio Zanetti,Maurizio Corbetta,Martijn P. van den Heuvel,Giovanni B. Frisoni,Rosa Manenti,Michela Pievani
标识
DOI:10.1016/j.neurobiolaging.2021.11.005
摘要
The default mode (DMN) and the salience (SN) networks show functional hypo-connectivity in Alzheimer's disease (AD) and the behavioral variant of frontotemporal dementia (bvFTD), respectively, along with patterns of hyper-connectivity. We tested the clinical and neurobiological effects of noninvasive stimulation over these networks in 45 patients (AD and bvFTD) who received either anodal (target network: DMN in AD, SN in bvFTD) or cathodal stimulation (target network: SN in AD, DMN in bvFTD). We evaluated changes in clinical, cognitive, functional and structural connectivity, and perfusion measures. In both patient groups, cathodal stimulation was followed by behavioral improvement, whereas anodal stimulation led to cognitive improvement. Neither functional connectivity nor perfusion showed significant effects. A significant interaction between DMN and SN functional connectivity changes and stimulation protocol was reported in AD. These results suggest a protocol-dependent response, whereby the protocols studied show divergent effects on cognitive and clinical measures, along with a divergent modulatory pattern of connectivity in AD.
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