Polydopamine-decorated black phosphorous to enhance stability in polymer scaffold

材料科学 脚手架 生物相容性 极限抗拉强度 聚合物 抗压强度 化学工程 粘附 复合材料 生物医学工程 冶金 医学 工程类
作者
Guoyong Wang,Guowen Qian,Jia Yao,Weiliang Cai,Shuping Peng,Cijun Shuai
出处
期刊:Nanotechnology [IOP Publishing]
卷期号:32 (45): 455701-455701 被引量:6
标识
DOI:10.1088/1361-6528/ac1977
摘要

Black phosphorous (BP) is recognized as an effective reinforcement for polymer scaffold because of its excellent mechanical property and biocompatibility. Nevertheless, its poor stability in physiological environment limits its application in bone repair. In this work, BP was modified with dopamine by self-polymerization approach (donated as BP@PDA) to improve its stability, and then was introduced into poly-L-lactic acid (PLLA) scaffold fabricated by selective laser sintering technology. Results showed the compressive and tensile strength of PLLA/BP@PDA scaffold were improved by 105% and 50%, respectively. The enhanced strength was ascribed to the increased stability of BP and the improved compatibility of BP@PDA with PLLA matrix after modifying with polydopamine. Simultaneously, the bioactivity of PLLA scaffold was significantly improved. It was attributed to that BP@PDA provided the sustained source of PO43- ions which could capture Ca2+ ions from physiological medium to facilitate in situ biomineralization, thereby promoting cell adhesion, proliferation and differentiation. This study demonstrated the great potential of BP@PDA in bone repair.
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