Primarily study of non-thermal tumor ablation method based on terahertz free electron laser

Non-thermal tumor ablation technology based on short pulse strong electric field can overcome the defects of thermal ablation and cryoablation, which provides a new opportunity for the development of tumor therapy. In this study, the CAEP terahertz free electron laser facility was preliminarily used to do the research on non-thermal tumor ablation method because of its unique macro-micro pulse time series. The biological effects of short pulse strong field terahertz radiation on melanoma cells and tissues were studied in vitro and in vivo. In vitro experiments show that the survival rate of tumor cells is significantly different after being irradiated by different frequency, power, and radiation duration of terahertz wave. Strong field terahertz wave can inhibit the proliferation of tumor cells. In vivo experiments showed that compared with the control group, the tumor tissue proliferation of the irradiated experimental group was slowed down, the tumor volume was gradually reduced, and the strong field terahertz pulses could inhibit the growth of tumor tissue. These preliminary results will provide a feasible reference for further research and long-term clinical application.