副溶血性弧菌
生物膜
运动性
微生物学
生物
细菌
生物信息学
病菌
弧菌科
细胞生物学
基因
生物化学
遗传学
作者
Dan Wang,Steve Flint,Dragana Gagić,John W. Palmer,Graham C. Fletcher,Stephen L.W. On
出处
期刊:Biofouling
[Informa]
日期:2021-07-03
卷期号:37 (6): 680-688
被引量:3
标识
DOI:10.1080/08927014.2021.1955357
摘要
The formation of biofilms is a survival strategy employed by bacteria to help protect them from changing or unfavourable environments. In this research, 319 genes which govern biofilm formation in V. parahaemolyticus, as reported in 1,625 publications, were analysed using protein-protein-interaction (PPI) network analysis. CsrA was identified as a motility-sessility switch and biofilm formation regulator. Through robust rank aggregation (RRA) analysis of GSE65340, the generation of viable but non-culturable (VBNC) cells that may enhance cell tolerance to stress, was found to be associated with the TCA cycle and carbon metabolism biological pathways. The finding that CsrA is likely to play a role in the development of VBNC cells improves understanding of the molecular mechanisms of VBNC formation in V. parahaemolyticus and contributes to on-going efforts to reduce the hazard posed by this foodborne pathogen.
科研通智能强力驱动
Strongly Powered by AbleSci AI