布氏锥虫
内吞作用
细胞生物学
生物
网格蛋白
纳米团簇
内质网
非洲锥虫病
细胞器
信号转导
锥虫病
生物化学
化学
病毒学
细胞
有机化学
基因
作者
Xinyi Wang,Di Zhang,Ning Jiang,Xiaofeng Wang,Naiwen Zhang,Kai Zhang,Xiaoyu Sang,Ying Feng,Ran Chen,Na Yang,Qijun Chen
出处
期刊:Nano Today
[Elsevier]
日期:2021-03-07
卷期号:38: 101122-101122
被引量:5
标识
DOI:10.1016/j.nantod.2021.101122
摘要
Trypanosoma brucei, the causative agent of African trypanosomiasis, is a unicellular protozoan with an intricate life cycle involving an insect vector and mammalian hosts. Trypanosomiasis remains a threat to the health of human beings and animals. Despite the rapid development of nanomedicine, there are few valuable reports on the application of nanoscience in protozoa, especially the lack of understanding of the mechanism. In this study, we investigated the endocytosis of two noble metal nanoclusters (NM-NCs), Ag2[email protected] and [email protected] in T. brucei. Both types of NC can be efficiently up-taken by T. brucei via a clathrin-dependent endocytosis pathway, and displayed in a dose-dependent anti-parasitic manner by inducing pathological alterations to apoptosis-associated organelles. The Ag2[email protected] mainly interacted with functional proteins in the mitochondrion and endoplasmic reticulum, while the [email protected] predominantly interfered with the biological activity of cytoplasmic enzymes involved in mRNA maturation, protein degradation and signal transduction. These data not only reveal the clathrin-dependent endocytosis pathway in T. brucei, but also open up a new avenue for NM-NC-based drug development for trypanosomiasis.
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