Intratumoral heterogeneity of surrogate molecular subtypes in urothelial carcinoma in situ of the urinary bladder: implications for prognostic stratification of high-risk non-muscle-invasive bladder cancer.

生物标志物 泌尿科 病理 膀胱切除术 尿路上皮 尿路上皮癌 癌症 淋巴血管侵犯 免疫组织化学 泌尿系统
作者
Stefan Garczyk,Felix Bischoff,Ursula Schneider,Reinhard Golz,Friedrich-Carl von Rundstedt,Ruth Knüchel,Stephan Degener
出处
期刊:Virchows Archiv [Springer Science+Business Media]
卷期号:479 (2): 325-335 被引量:1
标识
DOI:10.1007/s00428-021-03054-0
摘要

Reliable factors predicting the disease course of non-muscle-invasive bladder cancer (NMIBC) with carcinoma in situ (CIS) are unavailable. Molecular subtypes have potential for prognostic stratification of muscle-invasive bladder cancer, while their value for CIS patients is unknown. Here, the prognostic impact of both clinico-pathological parameters, including CIS focality, and immunohistochemistry-based surrogate subtypes was analyzed in a cohort of high-risk NMIBC patients with CIS. In 128 high-risk NMIBC patients with CIS, luminal (KRT20, GATA3, ERBB2) and basal (KRT5/6, KRT14) surrogate markers as well as p53 were analyzed in 213-231 biopsies. To study inter-lesional heterogeneity of CIS, marker expression in independent CIS biopsies from different bladder localizations was analyzed. Clinico-pathological parameters and surrogate subtypes were correlated with recurrence-free (RFS), progression-free (PFS), cancer-specific (CSS), and overall survival (OS). Forty-six and 30% of CIS patients exhibited a luminal-like (KRT20-positive, KRT5/6-negative) and a null phenotype (KRT20-negative, KRT5/6-negative), respectively. A basal-like subtype (KRT20-negative, KRT5/6-positive) was not observed. A significant degree of inter-lesional CIS heterogeneity was noted, reflected by 23% of patients showing a mixed subtype. Neither CIS surrogate subtype nor CIS focality was associated with patient outcome. Patient age and smoking status were the only potentially independent prognostic factors predicting RFS, PFS, OS, and PFS, respectively. In conclusion, further clarification of heterogeneity of surrogate subtypes in HR NMIBC and their prognostic value is of importance with regard to potential implementation of molecular subtyping into clinical routine. The potential prognostic usefulness of patient age and smoking status for high-risk NMIBC patients with CIS needs further validation.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
林博研发布了新的文献求助30
1秒前
1秒前
2秒前
muming发布了新的文献求助10
3秒前
5秒前
7秒前
充电宝应助NVLEKU采纳,获得10
7秒前
8秒前
8秒前
天天快乐应助zhu采纳,获得10
9秒前
IRer79发布了新的文献求助10
9秒前
量子星尘发布了新的文献求助10
9秒前
麦丰完成签到,获得积分10
9秒前
9秒前
likke完成签到,获得积分20
10秒前
10秒前
FashionBoy应助li采纳,获得10
11秒前
11秒前
SciGPT应助薛定谔的猫采纳,获得10
11秒前
12秒前
12秒前
muming完成签到,获得积分20
13秒前
sanlunainiu发布了新的文献求助10
13秒前
林博研完成签到,获得积分20
13秒前
FashionBoy应助风趣的灵枫采纳,获得10
14秒前
15秒前
yihuiqing发布了新的文献求助10
16秒前
likke发布了新的文献求助10
16秒前
嗝嗝发布了新的文献求助10
16秒前
小兔狸花昕完成签到,获得积分20
17秒前
IRer79完成签到,获得积分10
19秒前
彭于晏应助noah采纳,获得10
19秒前
青年才俊发布了新的文献求助10
19秒前
zhu发布了新的文献求助10
20秒前
波波蛋完成签到,获得积分10
20秒前
21秒前
22秒前
23秒前
maguodrgon发布了新的文献求助10
26秒前
高分求助中
(应助此贴封号)【重要!!请各用户(尤其是新用户)详细阅读】【科研通的精品贴汇总】 10000
Zeolites: From Fundamentals to Emerging Applications 1500
Architectural Corrosion and Critical Infrastructure 1000
Early Devonian echinoderms from Victoria (Rhombifera, Blastoidea and Ophiocistioidea) 1000
By R. Scott Kretchmar - Practical Philosophy of Sport and Physical Activity - 2nd (second) Edition: 2nd (second) Edition 666
Energy-Size Reduction Relationships In Comminution 500
Principles Of Comminution, I-Size Distribution And Surface Calculations 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 内科学 生物化学 物理 计算机科学 纳米技术 遗传学 基因 复合材料 化学工程 物理化学 病理 催化作用 免疫学 量子力学
热门帖子
关注 科研通微信公众号,转发送积分 4941339
求助须知:如何正确求助?哪些是违规求助? 4207390
关于积分的说明 13077624
捐赠科研通 3986257
什么是DOI,文献DOI怎么找? 2182529
邀请新用户注册赠送积分活动 1198125
关于科研通互助平台的介绍 1110387