Orange Trunk Waste-Based Lignin Nanoparticles Encapsulating Curcumin as a Photodynamic Therapy Agent against Liver Cancer

姜黄素 傅里叶变换红外光谱 动态光散射 木质素 纳米颗粒 核化学 扫描电子显微镜 纳米医学 化学工程 纳米囊 纳米技术 化学 材料科学 有机化学 生物化学 复合材料 工程类
作者
Deyvid de Souza Porto,Bianca Martins Estevão,Paula Maria Pincela Lins,Nathália Cristina Rissi,Valtencir Zucolotto,Maria Fátima das Graças Fernandes da Silva
出处
期刊:ACS applied polymer materials [American Chemical Society]
卷期号:3 (10): 5061-5072 被引量:17
标识
DOI:10.1021/acsapm.1c00822
摘要

Orange wood biomass is an interesting lignocellulosic material, but its lignin has been little explored. As a structural macromolecule present in the plant cell wall, lignin has been used in nanoencapsulation and nanomedicine, standing out as a good drug carrier. In this study, lignin was extracted by soda pulping process and used to produce nanoparticles for curcumin encapsulation and subsequent application in photodynamic therapy (PDT). The nanoparticles were synthesized by the solvent shifting process and characterized with UV–vis, fluorescence, dynamic light scattering (DLS), ζ-potential, and scanning electron microscopy (SEM). The lignin was soluble in organic solvent and presented an extraction yield of 20.6 ± 2%. The Fourier transform infrared (FTIR) spectroscopy and NMR signals showed that the lignin presents hardwood-type characteristics. The lignin nanoparticles were easily obtained and presented average sizes of 284 ± 60, 287 ± 60, and 502 ± 100 nm for pure lignin, 1% curcumin, and 5% curcumin nanoparticles, respectively. They exhibited a negative ζ-potential of about −42 ± 5 mV. The formulations were evaluated for 30 days and remained stable in phosphate-buffered saline (PBS). The curcumin encapsulation yields were high, above 90% in all formulations. Scanning electron microscopy (SEM) images showed that the nanoparticles are spherical and homogeneous. Studies using hepatocarcinoma (HTC) and HepaRG cells showed that the lignin nanoparticles were nontoxic within 4 h of incubation, and for nanoparticles containing 5% curcumin, toxicity was observed upon application of light in PDT experiments.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
勤奋的如松完成签到,获得积分0
3秒前
粥可温完成签到,获得积分10
5秒前
曾珍发布了新的文献求助10
6秒前
7秒前
hzh完成签到 ,获得积分10
8秒前
gg发布了新的文献求助10
8秒前
勤劳滑板完成签到 ,获得积分10
8秒前
Jerry完成签到,获得积分10
9秒前
MrLiu完成签到,获得积分10
10秒前
冷傲博完成签到,获得积分10
10秒前
jeff完成签到,获得积分10
10秒前
LHZ完成签到,获得积分10
10秒前
所所应助时尚俊驰采纳,获得10
11秒前
影子芳香完成签到 ,获得积分10
12秒前
13秒前
13秒前
不必要再讨论适合与否完成签到,获得积分0
14秒前
无情夏寒完成签到 ,获得积分10
15秒前
慕青应助马士全采纳,获得10
16秒前
xuzj应助科研通管家采纳,获得10
16秒前
Rubby应助科研通管家采纳,获得30
17秒前
SciGPT应助科研通管家采纳,获得10
17秒前
17秒前
17秒前
shiizii应助科研通管家采纳,获得10
17秒前
17秒前
17秒前
17秒前
ludong_0应助科研通管家采纳,获得10
17秒前
YeeYee发布了新的文献求助10
17秒前
冷酷的松思完成签到,获得积分10
17秒前
zgt01发布了新的文献求助10
18秒前
zhang完成签到,获得积分10
18秒前
江中完成签到 ,获得积分10
20秒前
20秒前
阿玖完成签到 ,获得积分10
21秒前
jiaolulu发布了新的文献求助10
23秒前
踏雪飞鸿完成签到,获得积分10
24秒前
hannah完成签到,获得积分10
24秒前
songvv发布了新的文献求助10
25秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038201
求助须知:如何正确求助?哪些是违规求助? 3575940
关于积分的说明 11373987
捐赠科研通 3305747
什么是DOI,文献DOI怎么找? 1819274
邀请新用户注册赠送积分活动 892662
科研通“疑难数据库(出版商)”最低求助积分说明 815022