光动力疗法
光毒性
癌细胞
阳离子聚合
细胞凋亡
癌症
细胞毒性
化学
材料科学
癌症研究
体外
生物
医学
生物化学
内科学
高分子化学
有机化学
作者
Yucheng Ma,Zeyan Zhuang,Longjiang Xing,Jianqing Li,Zhiwen Yang,Shaomin Ji,Rong Hu,Zujin Zhao,Yanping Huo,Ben Zhong Tang
标识
DOI:10.1002/adfm.202106988
摘要
Abstract The development of anticancer therapy is significant to human health but remains a huge challenge. Photodynamic therapy (PDT), inducing the synergistic mitochondrial dysfunction in cancer cells is a promising approach but suffer from the low efficiency in hypoxic microenvironment and deep‐seated tumors. Herein, to improve the outcomes of PDT for cancer treatment, a series of red fluorophores consisting of dual‐cationic triphenylphosphonium‐alkylated pyridinium and (substituted) triphenylamine are prepared as organelle‐targeting antitumor photosensitizers (PSs) with aggregation‐induced emission characteristics. These PSs can selectively accumulate at the mitochondria or lysosomes of cancer cells with both dark‐ and photo‐cytotoxicity, making them possess excellent killing effect on cancer cells and efficient inhibition of tumor growth in living mice. This study brings about new insight into the development of powerful cancer treatment.
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