阿苯达唑
生物
旋毛虫病
布尼卡
阿斯巴甜
幼虫
钴胺素
微生物学
兽医学
传统医学
毒理
蠕虫
食品科学
植物
动物
生物化学
医学
维生素B12
园艺
作者
Marwa Esmat,Amany Ahmed Abd El-Aal,Maisa Ahmed Shalaby,Mennat-Elrahman Ahmed Fahmy,Manal Badawi,Marwa A. Elmallawany,Mona Magdy,Adam Ashraf Afife,Iman R. Abdel-Shafi
标识
DOI:10.1590/s1984-29612021084
摘要
Trichinellosis is a zoonosis results from eating raw or semi-cooked meat of infected animals. Medicinal plants have been used lately as alternatives and/or combined therapies to resolve some drawbacks of the current regimens. This work analyzed the effect of albendazole monotherapy on Trichinella spiralis experimental infection (group A), in comparison to P. granatum and amygdalin extracts +cobalamin (group B), plus its combination with albendazole (group C). The study revealed that the extracts alone or combined with albendazole had an inferior effect to albendazole monotherapy regarding number of adult worms (40.83 ±3.82, 18.67 ±1.86 and 16.83 ±2.32, respectively). However, their effect was more obvious in muscle phase combined with albendazole, achieving the lower number of larvae/mL tissue homogenate (22.33 ±3.27 in comparison to 39.67 ±2.58 achieved by albendazole monotherapy). The extracts exerted a significant immunomodulatory effect by reducing the local CD4+ expression in the intestine as well as in muscle phase (1.15 ±0.25 and 3.80 ±0.65 in comparison to 4.97 ±0.37 and 12.20 ±0.87 with albendazole monotherapy, respectively). So, these extracts improved the therapeutic efficacy of albendazole, specifically in muscle phase and counteracted the inflammatory reaction caused by albendazole monotherapy, thus extensively alleviating the resulting myositis.
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