化学
单线态氧
卟啉
光敏剂
取代基
光化学
量子产额
衍生工具(金融)
三唑
分子
光动力疗法
单重态
荧光
氧气
药物化学
有机化学
激发态
核物理学
经济
物理
金融经济学
量子力学
作者
Kevser Harmandar,Gülenay Tunç,Tuğba Küçük,Ayşe Gül Gürek,Devrim Atílla
标识
DOI:10.1142/s1088424621500875
摘要
In this study, a novel asymmetrically meso-substituted AB 3 porphyrins derivative including one triazole group to enhance the anticancer activity of the molecule and three bromophenyl groups to improve photochemical properties has been synthesized and characterized. Our objectives were to generate a system with triazole and bromophenyl groups that enhance the singlet oxygen generation and exhibits an anti-cancer effect. Therefore, photophysical and photochemical properties of this asymmetric porphyrin derivative (AB[Formula: see text] and the symmetric derivative (B[Formula: see text] were investigated in THF. The substituent effect on fluorescence quantum yield and singlet oxygen generation was evaluated for efficiency in photodynamic therapy (PDT) as a photosensitizer. The molecules exhibited no aggregation tendency, solubility in common organic solvents and high singlet oxygen quantum yield in THF therefore these favorable properties make them good candidates as a photosensitizer for PDT.
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