Recent Advances on Optical Detection Methods and Techniques for Cell-Based Microfluidic Systems

Recent advances on optical detection methods and techniques applied in cell-based microfluidic systems are reviewed.Microsystems that integrate on chip cell culture and real-time detection,and recent advances on correlated detection methods and techniques are mainly focused.Comparison of six optical detection methods and techniques are summarized,and their research applicability for cell study is proposed.Trend and development perspective of each technique applied for living cell label-free and real-time detection and sensing are discussed.Finally,an assessment of future directions for lab chip based cell research and sensing microsystem are concluded.