核糖核酸
计算生物学
核酸结构
核糖开关
生物
转录组
非编码RNA
遗传学
基因表达
基因
作者
Xiwen Wang,Chu‐Xiao Liu,Ling‐Ling Chen,Qiangfeng Cliff Zhang
标识
DOI:10.1038/s41589-021-00805-7
摘要
RNA molecules fold into complex structures that enable their diverse functions in cells. Recent revolutionary innovations in transcriptome-wide RNA structural probing of living cells have ushered in a new era in understanding RNA functions. Here, we summarize the latest technological advances for probing RNA secondary structures and discuss striking discoveries that have linked RNA regulation and biological processes through interrogation of RNA structures. In particular, we highlight how different long noncoding RNAs form into distinct secondary structures that determine their modes of interactions with protein partners to realize their unique functions. These dynamic structures mediate RNA regulatory functions through altering interactions with proteins and other RNAs. We also outline current methodological hurdles and speculate about future directions for development of the next generation of RNA structure-probing technologies of higher sensitivity and resolution, which could then be applied in increasingly physiologically relevant studies.
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