Cumulative Risk Assessment of Exposure to Heavy Metals through Aquatic Products in China.

This study aimed to assess the risk of cumulative exposure to Pb, Cd, Hg, and iAs through aquatic products consumed by Chinese people.Heavy metal concentration data were obtained from the national food contamination monitoring program during 2013-2017. Consumption data were derived from the China National Food Consumption Survey in 2014 and the relative potency factor (RPF) method was used to estimate cumulative exposure for neurotoxicity and nephrotoxicity.The results demonstrated that the cumulative exposure based on neurotoxicity was below the lower confidence limit on benchmark doses of lead (BMDL 01) for nephrotoxicity and the cumulative exposures were all lower than the provisional tolerable monthly intake (PTMI) of Cd. However, the margin of exposure values (MOEs) of the cumulative exposures for neurotoxicity in the 2-6 year-old group was close to 1 and the cumulative exposure level for nephrotoxicity accounted for 90.21 % of the PTMI.The cumulative exposures of the 2-6 year-old group to the four heavy metals did not reach (but came close to) the corresponding safety threshold for both neurotoxicity and nephrotoxicity. Given that there are still other food sources of these four heavy metals, it is necessary to more closely study their cumulative health effects.