炎症
巨噬细胞
医学
细胞凋亡
程序性细胞死亡
免疫学
疾病
动脉粥样硬化性心血管疾病
生物
病理
体外
生物化学
出处
期刊:Nature Reviews Immunology
[Springer Nature]
日期:2009-12-04
卷期号:10 (1): 36-46
被引量:974
摘要
An important aspect of atherosclerosis is the defective resolution of the inflammatory response to subendothelial lipoproteins. But what are the pathways involved in inflammation resolution, why are they defective in atherosclerotic lesions and how can they be therapeutically targeted? A key event in atherosclerosis is a maladaptive inflammatory response to subendothelial lipoproteins. A crucial aspect of this response is a failure to resolve inflammation, which normally involves the suppression of inflammatory cell influx, effective clearance of apoptotic cells and promotion of inflammatory cell egress. Defects in these processes promote the progression of atherosclerotic lesions into dangerous plaques, which can trigger atherothrombotic vascular disease, the leading cause of death in industrialized societies. In this Review I provide an overview of these concepts, with a focus on macrophage death and defective apoptotic cell clearance, and discuss new therapeutic strategies designed to boost inflammation resolution in atherosclerosis.
科研通智能强力驱动
Strongly Powered by AbleSci AI