清脆的
生物
回文
反式激活crRNA
细菌
基因组
遗传学
机制(生物学)
功能(生物学)
Cas9
核糖核酸
计算生物学
古细菌
基因
哲学
认识论
作者
Rotem Sorek,Victor Kunin,Philip Hugenholtz
摘要
CRISPR systems, which are composed of direct repeats that are separated by similarly sized non-repetitive spacers, confer resistance to phages in many bacteria and most archaea. This new antiviral tactic is thought to involve an RNA-interference-like mechanism, and is reviewed in this Progress article. Arrays of clustered, regularly interspaced short palindromic repeats (CRISPRs) are widespread in the genomes of many bacteria and almost all archaea. These arrays are composed of direct repeats that are separated by similarly sized non-repetitive spacers. CRISPR arrays, together with a group of associated proteins, confer resistance to phages, possibly by an RNA-interference-like mechanism. This Progress discusses the structure and function of this newly recognized antiviral mechanism.
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