化学
钯
劈理(地质)
纳米技术
细胞内
组合化学
催化作用
生物物理学
生物化学
断裂(地质)
生物
工程类
岩土工程
材料科学
作者
Muhammad Rahimi Yusop,Asier Unciti‐Broceta,Emma M. Björk,Rosario M. Sánchez‐Martín,Mark Bradley
出处
期刊:Nature Chemistry
[Springer Nature]
日期:2011-02-06
卷期号:3 (3): 239-243
被引量:455
摘要
Many important intracellular biochemical reactions are modulated by transition metals, typically in the form of metalloproteins. The ability to carry out selective transformations inside a cell would allow researchers to manipulate or interrogate innumerable biological processes. Here, we show that palladium nanoparticles trapped within polystyrene microspheres can enter cells and mediate a variety of Pd0-catalysed reactions, such as allylcarbamate cleavage and Suzuki–Miyaura cross-coupling. The work provides the basis for the customization of heterogeneous unnatural catalysts as tools to carry out artificial chemistries within cells. Such in cellulo synthesis has potential for a plethora of applications ranging from cellular labelling to synthesis of modulators or inhibitors of cell function. Palladium nanoparticles trapped within polystyrene beads can enter cells and mediate a variety of Pd0-catalysed reactions, including allylcarbamate cleavage and Suzuki–Miyaura cross-coupling. The methodology presented provides the basis for the customization of heterogeneous unnatural catalysts as tools for carrying out artificial chemistries within cells.
科研通智能强力驱动
Strongly Powered by AbleSci AI