埃博拉病毒
丝虫科
病毒学
生物
马尔堡病毒
埃博拉病毒
爆发
人类免疫缺陷病毒(HIV)
病毒性疾病
副粘病毒科
作者
Paolo Ascenzi,Alessio Bocedi,J Heptonstall,Maria Rosaria Capobianchi,Giovanni Di Perri,Eloise Mastrangelo,Martino Bolognesi,Giuseppe Ippolito
标识
DOI:10.1016/j.mam.2007.09.005
摘要
Ebolavirus and Marburgvirus (belonging to the Filoviridae family) emerged four decades ago and cause epidemics of haemorrhagic fever with high case-fatality rates. The genome of filoviruses encodes seven proteins. No significant homology is observed between filovirus proteins and any known macromolecule. Moreover, Marburgvirus and Ebolavirus show significant differences in protein homology. The natural maintenance cycle of filoviruses is unknown, the natural reservoir, the mode of transmission, the epidemic disease generation, and temporal dynamics are unclear. Lastly, Ebolavirus and Marburgvirus are considered as potential biological weapons. Vaccine appears the unique therapeutic frontier. Here, molecular and clinical aspects of filoviral haemorrhagic fevers are summarized.
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