Neurodegeneration in Amygdala Precedes Hippocampus in the APPswe/ PS1dE9 Mouse Model of Alzheimer’s Disease

扁桃形结构 海马体 神经科学 神经退行性变 海马结构 阿尔茨海默病 心理学 基底外侧杏仁核 内科学 医学 疾病
作者
Tzu Wei Lin,Yu Fan Liu,Ying-Hsia Shih,Shean-Jen Chen,Tai Yin Huang,Chia Yuan Chang,Chi-Hsiang Lien,Lung Yu,Shun Hua Chen,Yu Min Kuo
出处
期刊:Current Alzheimer Research [Bentham Science Publishers]
卷期号:12 (10): 951-963 被引量:14
标识
DOI:10.2174/1567205012666151027124938
摘要

Both the hippocampus and amygdala are early vulnerable brain regions in the development of Alzheimer’s disease (AD). However, previous studies mainly focused on characterizing the hippocampus in the pathophysiology of AD, leaving the amygdala less explored. Here, we characterized the structures and functions of neurons in the hippocampus and amygdala of young (2, 3 and 4 months of age) APP/PS1 double transgenic (Tg) mice, a widely used AD mouse model. Compared to wild-type littermates (Wt ), Tg mice performed worse in amygdala-dominant memory at all three ages, while hippocampus-dominant memory remained intact until 4-month-old. Likewise, the dendritic arbors of neurons in the basolateral amygdala were reduced in Tg mice as early as 2-months-old, while the dendritic arbors of neurons in the hippocampal CA1 and CA3 regions were relatively intact. BDNF signaling pathways (e.g. AKT and PKC) were reduced in the amygdala, but not in the hippocampus, of young Tg mice. Furthermore, reduction of 5-HT and elevation of Aβ levels also occurred earlier in the amygdala and were more pronounced than those in the hippocampus. Negative correlations between the levels of 5-HT and Aβ were evident in the amygdala, but not in the hippocampus. Taken together, these results suggest that neurodegeneration occurs earlier in the amygdala than in the hippocampus. We suggest that amygdala function should be incorporated into the cognitive screening tool for the diagnosis of mild cognitive impairment due to AD. Keywords: Alzheimer’s disease, amygdala, dendrite, hippocampus, learning and memory, plasticity.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
lizhiqian2024完成签到,获得积分10
2秒前
Arrhenius完成签到,获得积分10
3秒前
悠悠完成签到 ,获得积分10
4秒前
人不犯二枉少年完成签到,获得积分10
5秒前
5秒前
研友_Lw7MKL完成签到,获得积分10
5秒前
Alan完成签到,获得积分10
6秒前
葳葳发布了新的文献求助10
6秒前
6秒前
8秒前
8秒前
在险峰发布了新的文献求助10
9秒前
正直的沛凝完成签到,获得积分10
9秒前
10秒前
11秒前
海鸥完成签到,获得积分10
11秒前
蒋若风完成签到,获得积分10
11秒前
爆米花应助孙文杰采纳,获得10
12秒前
小艾完成签到,获得积分10
12秒前
明理萃完成签到 ,获得积分10
13秒前
苏黎世发布了新的文献求助10
13秒前
14秒前
乔安发布了新的文献求助10
14秒前
炫哥IRIS发布了新的文献求助10
14秒前
LaTeXer给积极行天的求助进行了留言
15秒前
ww发布了新的文献求助10
15秒前
Carlo完成签到,获得积分10
16秒前
蓝胖子完成签到 ,获得积分10
17秒前
18秒前
终生科研徒刑完成签到 ,获得积分10
18秒前
19秒前
ysc发布了新的文献求助20
21秒前
22秒前
LKX完成签到 ,获得积分10
22秒前
纯真的诗兰完成签到,获得积分10
23秒前
自然函完成签到 ,获得积分10
23秒前
等一个晴天完成签到,获得积分10
24秒前
as发布了新的文献求助100
24秒前
天天快乐应助科研通管家采纳,获得10
24秒前
研友_VZG7GZ应助科研通管家采纳,获得10
24秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038446
求助须知:如何正确求助?哪些是违规求助? 3576149
关于积分的说明 11374627
捐赠科研通 3305875
什么是DOI,文献DOI怎么找? 1819354
邀请新用户注册赠送积分活动 892680
科研通“疑难数据库(出版商)”最低求助积分说明 815048