光热治疗
癌症治疗
细胞外基质
放射治疗
癌症
酶
纳米技术
生物物理学
酶分析
癌细胞
化学
癌症研究
材料科学
生物化学
医学
生物
内科学
作者
Jingchao Li,Chen Xie,Jiaguo Huang,Yuyan Jiang,Qingqing Miao,Kanyi Pu
标识
DOI:10.1002/anie.201800511
摘要
Abstract Regulation of enzyme activity is fundamentally challenging but practically meaningful for biology and medicine. However, noninvasive remote control of enzyme activity in living systems has been rarely demonstrated and exploited for therapy. Herein, we synthesize a semiconducting polymer nanoenzyme with photothermic activity for enhanced cancer therapy. Upon near‐infrared (NIR) light irradiation, the activity of the nanoenzyme can be enhanced by 3.5‐fold to efficiently digest collagen in the tumor extracellular matrix (ECM), leading to enhanced nanoparticle accumulation in tumors and consequently improved photothermal therapy (PTT). This study thus provides a promising strategy to remotely regulate enzyme activity for cancer therapy.
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