对映选择合成
化学
烷基化
双金属片
卤化物
烷基
有机化学
组合化学
催化作用
作者
Yang Xiong,Guozhu Zhang
摘要
A highly enantioselective three-component coupling of 1,3-butadiene with a variety of fluorinated or nonfluorinated alkyl halides and aldehydes has been achieved relying on a Cr/Co bimetallic catalysis system. The strategy established here facilitates straightforward introduction of the privileged fluoro functionalities into homoallylic alcohols from bulk feedstock materials in a highly anti-diastereo and enantioselective manner.
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