RhIII-Catalyzed site-selective amidation with nitrone as a traceless directing group: an approach to functionalized arylaldehydes

An efficient Rh-catalyzed site-selective amidation of nitrones with 1,4,2-dioxazol-5-ones has been developed. The reaction can tolerate a number of groups and generates functionalized aldehydes in good yields. The significance of the amidation is highlighted by the late-stage transformation of the formed aldehydes.