小胶质细胞
神经科学
神经炎症
吞噬作用
免疫系统
睡眠(系统调用)
炎症
心理学
生物
免疫学
计算机科学
操作系统
作者
Agnès Nadjar,Henna‐Kaisa Wigren,Marie‐Ève Tremblay
标识
DOI:10.3389/fncel.2017.00250
摘要
Sleep serves crucial learning and memory functions in both nervous and immune systems. Microglia are brain immune cells that actively maintain health through their crucial physiological roles exerted across the lifespan, including phagocytosis of cellular debris and orchestration of neuroinflammation. The past decade has witnessed an explosive growth of microglial research. Considering the recent developments in the field of microglia and sleep, we examine their possible impact on various pathological conditions associated with a gain, disruption or loss of sleep in this focused mini-review. While there are extensive studies of microglial implication in a variety of neuropsychiatric and neurodegenerative diseases, less is known regarding their roles in sleep disorders. It is timely to stimulate new research in this emergent and rapidly growing field of investigation.
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