Admission for COPD Exacerbation Is Associated with the Clinical Diagnosis of Pulmonary Hypertension: Results from a Retrospective Longitudinal Study of a Veteran Population

慢性阻塞性肺病 医学 恶化 内科学 回顾性队列研究 诊断代码 重症监护医学 人口 环境卫生
作者
Sarah Medrek,Amir Sharafkhaneh,Andrew Spiegelman,Arnav Kak,Lavannya M. Pandit
出处
期刊:COPD: Journal of Chronic Obstructive Pulmonary Disease [Informa]
卷期号:14 (5): 484-489 被引量:42
标识
DOI:10.1080/15412555.2017.1336209
摘要

Patients with chronic obstructive pulmonary disease and pulmonary hypertension (PH–COPD) have an increased risk of hospitalizations and death compared to COPD alone. Identifying PH in COPD is challenging because performing right heart catheterization, the gold standard for PH diagnosis, is invasive and not routinely performed. Clinical characterization of COPD patients at risk who are progressing toward PH will aid therapeutic development at earlier stages of progressively fatal PH–COPD. We studied the records of 5,45,086 patients in a large Veterans Affairs healthcare network (2000–2012) with a primary discharge diagnosis of COPD based on encounters' ICD-9 codes and further stratified into those who received an additional ICD-9 code for a PH diagnosis. Patients with PH–COPD were assigned to one of the four subgroups: those with (a) no history of exacerbation or hospital admissions, (b) history of exacerbations but no hospital admissions, (c) hospital admissions unrelated to COPD and (d) history of COPD exacerbation-related hospital admissions. We also examined the COPD and COPD-PH cohorts for associated comorbidities such as cardiac disease and the presence of obstructive sleep apnea (OSA). A regression analysis revealed that patients with COPD exacerbation-related hospital admissions had 7 × higher risk of having a concomitant clinical diagnosis of PH compared to non-hospitalized patients. COPD-PH patients had higher rates of cardiac comorbidities (89% vs. 66%) and OSA (34% vs. 16%) compared to COPD alone. We conclude that COPD patients hospitalized for COPD exacerbations are at a higher risk for developing PH, and hospitalized COPD patients with cardiac comorbidities and/or OSA should be screened as at-risk population for developing PH.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
王手发布了新的文献求助10
1秒前
1秒前
1秒前
烟花应助zzq778采纳,获得10
3秒前
3秒前
欣欣发布了新的文献求助10
3秒前
小欣6116发布了新的文献求助10
4秒前
Jiuhui发布了新的文献求助10
4秒前
御风甜咖啡完成签到,获得积分10
4秒前
uupp完成签到,获得积分10
5秒前
机智雁凡完成签到,获得积分10
6秒前
Cheung2121发布了新的文献求助30
7秒前
8秒前
10秒前
谜记完成签到,获得积分10
10秒前
共享精神应助Cheung2121采纳,获得30
10秒前
光撒盐完成签到,获得积分10
11秒前
cowboy007完成签到,获得积分10
11秒前
张振宇完成签到 ,获得积分10
12秒前
zz发布了新的文献求助10
13秒前
zzq778发布了新的文献求助10
15秒前
黄怡婷完成签到 ,获得积分10
15秒前
Daisy应助科研通管家采纳,获得10
16秒前
机智苗应助科研通管家采纳,获得10
16秒前
香蕉觅云应助科研通管家采纳,获得10
16秒前
FashionBoy应助科研通管家采纳,获得10
16秒前
赘婿应助科研通管家采纳,获得10
16秒前
大模型应助科研通管家采纳,获得10
16秒前
yanmu2010应助科研通管家采纳,获得10
16秒前
kingwill应助科研通管家采纳,获得20
17秒前
银包铜应助科研通管家采纳,获得10
17秒前
共享精神应助科研通管家采纳,获得10
17秒前
17秒前
情怀应助科研通管家采纳,获得10
17秒前
李爱国应助科研通管家采纳,获得10
17秒前
所所应助科研通管家采纳,获得10
17秒前
17秒前
Orange应助科研通管家采纳,获得10
17秒前
17秒前
17秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038368
求助须知:如何正确求助?哪些是违规求助? 3576068
关于积分的说明 11374313
捐赠科研通 3305780
什么是DOI,文献DOI怎么找? 1819322
邀请新用户注册赠送积分活动 892672
科研通“疑难数据库(出版商)”最低求助积分说明 815029