牛磺酸
慢性阻塞性肺病
发病机制
微粒
香烟烟雾
线粒体
生物
化学
生物化学
医学
内科学
免疫学
毒理
氨基酸
生态学
作者
Xiaobo Li,Hongbao Yang,Hao Sun,Runze Lu,Chengcheng Zhang,Na Gao,Qingtao Meng,Shenshen Wu,Susanna Wang,Michael Aschner,Jiong Wu,Boping Tang,Aihua Gu,Steve A. Kay,Rui Chen
标识
DOI:10.1073/pnas.1712465114
摘要
Significance Exposure to high levels of particulate matter (PM) poses a major threat to human health. Cigarette smoke is the most common irritant that causes chronic obstructive pulmonary disease (COPD); however, at least one-fourth of patients with COPD are nonsmokers, and their disease is largely attributed to air pollution. The occurrence of pollution episodes in China has raised an emergent question of how PM leads to the pathogenesis of COPD. In this paper, we show that deregulation of mitochondrial NADH dehydrogenase gene expression levels plays a key role in the aggravation of COPD during air pollutant exposure, which can be rescued by taurine and 3-MA treatments in both mammalian cells and animals.
科研通智能强力驱动
Strongly Powered by AbleSci AI