坏死性小肠结肠炎
丁酸梭菌
医学
青霉素
小肠结肠炎
微生物学
梭菌
抗生素
儿科
胃肠病学
细菌
生物
遗传学
作者
Randall Sturm,Joseph L. Staneck,L R Stauffer,Wallace W. Neblett
出处
期刊:Pediatrics
[American Academy of Pediatrics]
日期:1981-04-01
卷期号:67 (4): 569-569
被引量:58
标识
DOI:10.1542/peds.67.4.569
摘要
The cause of neonatal necrotizing enterocolitis (NEC) is unknown. An association between NEC and clostridial infection has been reported from several centers, but the organisms have not been extensively characterized. Clostridium butyricum was isolated from the peritoneal fluid and cerebrospinal fluid of a neonate with NEC. The organism was resistant to the penicillins, but sensitive to vancomycin. Toxin production was demonstrated. Although the role of clostridial toxins in the pathogenesis of NEC is unknown, clostridial toxins are well established as the causes of two other intestinal diseases (antibiotic-associated pseudomembranous colitis and pig-bel). Further investigation of the role of clostridia in the pathogenesis of NEC and of the use of oral, nonabsorbable antibiotics in the treatment of NEC is needed.
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