The role of estrogen in cutaneous ageing and repair

雌激素 医学 老化 内科学
作者
Holly N. Wilkinson,Matthew J. Hardman
出处
期刊:Maturitas [Elsevier BV]
卷期号:103: 60-64 被引量:124
标识
DOI:10.1016/j.maturitas.2017.06.026
摘要

Combined advances in modern medical practice and increased human longevity are driving an ever-expanding elderly population. Females are particularly at risk of age-associated pathology, spending more of their lives in a post-menopausal state. Menopause, denoted by a rapid decline in serum sex steroid levels, accelerates biological ageing across the body's tissues. Post-menopause physiological changes are particularly noticeable in the skin, which loses structural architecture and becomes prone to damage. The sex steroid most widely discussed as an intrinsic contributor to skin ageing and pathological healing is 17β-estradiol (or estrogen), although many others are involved. Estrogen deficiency is detrimental to many wound-healing processes, notably inflammation and re-granulation, while exogenous estrogen treatment widely reverses these effects. Over recent decades, many of the molecular and cellular correlates to estrogen's beneficial effect on normal skin homeostasis and wound healing have been reported. However, disparities still exist, particularly in the context of mechanistic studies investigating estrogen receptor signalling and its potential cellular effects. New molecular techniques, coupled with increased understanding of estrogen in skin biology, will provide further opportunities to develop estrogen receptor-targeted therapeutics.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
黑猫发布了新的文献求助10
刚刚
坚强幼晴发布了新的文献求助10
刚刚
哈哈完成签到,获得积分20
1秒前
吉吉发布了新的文献求助10
2秒前
lize5493完成签到,获得积分10
2秒前
Melodie完成签到,获得积分10
2秒前
热心市民小红花应助123采纳,获得10
3秒前
油饼完成签到,获得积分10
4秒前
量子星尘发布了新的文献求助10
5秒前
徐璇完成签到,获得积分10
5秒前
星辰完成签到,获得积分10
7秒前
8秒前
8秒前
8秒前
9秒前
11秒前
6666发布了新的文献求助10
13秒前
无限雨南发布了新的文献求助10
13秒前
EgoElysia完成签到,获得积分10
13秒前
敏感雅香发布了新的文献求助10
14秒前
归尘发布了新的文献求助150
15秒前
zumri发布了新的文献求助10
15秒前
jia完成签到,获得积分10
17秒前
18秒前
18秒前
hino发布了新的文献求助10
18秒前
共享精神应助6666采纳,获得10
20秒前
shower_009完成签到,获得积分10
21秒前
23秒前
在水一方应助哈哈采纳,获得10
24秒前
24秒前
纯真追命完成签到 ,获得积分10
24秒前
24秒前
25秒前
咚咚锵完成签到,获得积分10
25秒前
25秒前
包容的琦发布了新的文献求助30
28秒前
梦里繁花发布了新的文献求助10
28秒前
Wang完成签到,获得积分10
30秒前
weilanhaian完成签到,获得积分10
30秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3988868
求助须知:如何正确求助?哪些是违规求助? 3531255
关于积分的说明 11253071
捐赠科研通 3269858
什么是DOI,文献DOI怎么找? 1804822
邀请新用户注册赠送积分活动 881994
科研通“疑难数据库(出版商)”最低求助积分说明 809035