近距离放射治疗
材料科学
克尔玛
吸收剂量
剂量学
量热计(粒子物理)
核医学
光学
物理
探测器
放射治疗
医学
内科学
作者
Arman Sarfehnia,Jan Seuntjens
摘要
Parameters influencing the accuracy of absorbed dose measurements for HDR 192Ir brachytherapy using water calorimetry were investigated with the goal to develop a novel primary absorbed dose to water standard. To provide greater stability, flexibility, and accuracy in the source-detector distance dsrc-det positioning and measurement, a new spring-loaded catheter holder composed of two concentric cylindrical sleeves with multiple orthogonal adjusting screws was developed. The absorbed dose from Nucletron microSelectron-HDR 192Ir brachytherapy sources with air kerma strengths ranging between 21000-38000 U was studied. dsrc-det is optimized so as to balance signal-to-noise ratio (decreasing with increasing dsrc-det ) and temperature drift effects resulting from source self-heating. The irradiation times were adjusted to yield a minimum 1 Gy of dose at the measurement point. Successful measurements at dsrc-det ranging between 25-50 mm were performed. COMSOL MULTIPHYSICS™ software was used to determine the heat loss correction due to conduction defined as the ratio between temperature rise at a point under ideal conditions to realistic conditions (i.e., no conduction). An agreement of better than 6.5% was observed between TG-43 calculated and calorimetrically measured absorbed dose rates. The effects of convection where calculated to be negligible as the glass vessel provides a convective barrier significantly decoupling the water velocity in the interior and exterior of the vessel (water velocities were 1-2 orders of magnitude different). Our work paves the way to successful primary absorbed dose determination for radioactive sources using calorimetric techniques.
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