医学
乌斯特基努马
克罗恩病
炎症性肠病
肿瘤坏死因子α
肿瘤坏死因子
克罗恩病
阿达木单抗
疾病
内科学
胃肠病学
作者
Uri Kopylov,Waqqas Afif,A Cohen,Alain Bitton,Gary Wild,Talat Bessissow,Jonathan Wyse,Talal Al-Taweel,Andrew Szilagyi,Ernest G. Seidman
出处
期刊：Journal of Crohn's and Colitis
[Oxford University Press]
日期：2014-07-02
卷期号：8 (11): 1516-1522
被引量：137
标识
DOI：10.1016/j.crohns.2014.06.005
摘要
Background: Ustekinumab is a fully human IgG1 monoclonal antibody that blocks the biologic activity of interleukin-12/23. Ustekinumab is approved for treatment of plaque psoriasis and has been shown to be effective for induction and maintenance of clinical response in anti-TNF resistant Crohn's disease (CD). The aim of the study was to describe the real-life experience with open-label use of ustekinumab in anti-TNF resistant CD patients.
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