As per our knowledge, for the first time in India, cord blood glucose, insulin, and cortisol levels in preterm and term newborns were estimated and insulin resistance was calculated using HOMA-IR, QUICKI, and glucose insulin ratio.Thrifty phenotype hypothesis states that the etiology of type 2 diabetes mellitus occurs early during intrauterine development.In few studies, term newborns' cord blood glucose, insulin, homeostasis model assessment of insulin resistance (HOMA-IR), and quantitative insulin sensitivity check index (QUICKI) were reported.