药物输送
纳米技术
纳米囊
胶束
纳米颗粒
聚合物
材料科学
智能聚合物
控制释放
毒品携带者
化学
有机化学
复合材料
水溶液
作者
Manuel Alatorre‐Meda,Carmen Alvarez‐Lorenzo,Ángel Concheiro,Pablo Taboada
出处
期刊:The Royal Society of Chemistry eBooks
[The Royal Society of Chemistry]
日期:2013-04-17
卷期号:: 304-348
被引量:25
标识
DOI:10.1039/9781849736800-00304
摘要
Nano- and micro-carriers were originally conceived to release active molecules passively via diffusion or upon long-term erosion. However, with the help of novel, minimally invasive technologies, which enable their remotely induced disruption, these systems have evolved to become smart carriers able to release substances upon subtle structural changes in response to certain physiological environments/processes or external applied stimuli. In the present chapter, light-responsive polymer-based drug-delivery systems are reviewed in terms of i) interactions of light with the biological tissues and the repercussions on the use of light as an external stimulus for drug delivery and related applications; ii) materials and methodologies useful for their preparation; iii) mechanisms by which the light-responsiveness is imparted; and iv) structure of the carriers and applications for drug release. Representative examples of ultra-violet (UV) and near-infrared (near-IR) light-responsive polymeric micelles, polymersomes, micro-/nanocapsules and micro-/nanoparticles for drug delivery are discussed from the point of view of their composition, preparation, mechanism involved in irradiation induced release and potential clinical applications.
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