Effect of short-term high-dose atorvastatin on systemic inflammatory response and myocardial ischemic injury in patients with unstable angina pectoris undergoing percutaneous coronary intervention

医学 传统PCI 阿托伐他汀 经皮冠状动脉介入治疗 心肌梗塞 肌钙蛋白I 内科学 不稳定型心绞痛 心脏病学 肌酸 肌酸激酶 装载剂量 心绞痛 肌钙蛋白T
作者
Fei Sun,Zhao Yin,Qi Shi,Bei Zhao,Shouli Wang
出处
期刊:Chinese Medical Journal [Lippincott Williams & Wilkins]
卷期号:127 (21): 3732-3737 被引量:2
标识
DOI:10.3760/cma.j.issn.0366-6999.20141199
摘要

Background Percutaneous coronary intervention (PCI) could develop periprocedural myocardial infarction and inflammatory response and statins can modify inflammatory responses property. The aim of this study was to evaluate whether short-term high-dose atorvastatin therapy can reduce inflammatory response and myocardial ischemic injury elicited by PCI. Methods From March 2012 to May 2014, one hundred and sixty-five statin-naive patients with unstable angina referred for PCI at Department of Cardiology of the 306th Hospital, were enrolled and randomized to 7-day pretreatment with atorvastatin 80 mg/d as high dose group (HD group, n =56) or 20 mg/d as normal dose group (ND group, n =57) or an additional single high loading dose (80 mg) followed 6-day atorvastatin 20 mg/d as loading dose group (LD group, n =52). Plasma C-reactive protein (CRP) and interleukin-6 (IL-6) levels were determined before intervention and at 5 minutes, 24 hours, 48 hours, 72 hours, and 7 days after intervention. Creatine kinase-myocardial isoenzyme (CK-MB) and cardiac troponin I (cTnI) were measured at baseline and then 24 hours following PCI. Results Plasma CRP and IL-6 levels increased from baseline after PCI in all groups. CRP reached a maximum at 48 hours and IL-6 level reached a maximum at 24 hours after PCI. Plasma CRP levels at 24 hours after PCI were significantly lower in the HD group ((9.14±3.02) mg/L) than in the LD group ((11.06±3.06) mg/L) and ND group ((12.36±3.08) mg/L, P <0.01); this effect persisted for 72 hours. IL-6 levels at 24 hours and 48 hours showed a statistically significant decrease in the HD group ((16.19±5.39) ng/L and (14.26±4.12) ng/L, respectively)) than in the LD group ((19.26±6.34) ng/L and (16.03±4.08) ng/L, respectively, both P <0.05) and ND group ((22.24±6.98) ng/L and (17.24±4.84) ng/L, respectively). IL-6 levels at 72 hours and 7 days showed no statistically significant difference among the study groups. Although PCI caused a significant increase in CK-MB and cTnI at 24 hours after the procedure in all groups, the elevated CK-MB and cTnI values were lower in the HD group ((4.71±4.34) ng/ml and (0.086±0.081) ng/ml, respectively) than in the ND group ((7.24±6.03) ng/ml and (0.138±0.103) ng/ml, respectively, both P <0.01) and LD group ((6.80±5.53) ng/ml and (0.126±0.101) ng/ml, respectively, both P <0.01). Conclusion Short-term high-dose atorvastatin treatment before PCI significantly reduced systemic inflammatory response and myocardial ischemic injury elicited by PCI.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
HH完成签到 ,获得积分10
刚刚
寒冷归尘完成签到,获得积分20
1秒前
Owen应助HY采纳,获得10
1秒前
2秒前
复杂听筠发布了新的文献求助30
2秒前
爆米花应助椰子采纳,获得10
2秒前
3秒前
银匠完成签到,获得积分10
3秒前
tyy发布了新的文献求助10
3秒前
3秒前
4秒前
4秒前
wenwen完成签到,获得积分10
4秒前
上善若水发布了新的文献求助10
4秒前
LLL完成签到,获得积分10
5秒前
寒冷归尘发布了新的文献求助10
5秒前
玖生发布了新的文献求助10
5秒前
5秒前
6秒前
6秒前
6秒前
123zyuyu完成签到,获得积分10
7秒前
7秒前
Dave完成签到 ,获得积分0
7秒前
7秒前
可爱的函函应助嘿嘿采纳,获得10
7秒前
小茉莉发布了新的文献求助30
8秒前
zhuzhu完成签到,获得积分10
8秒前
8秒前
海海发布了新的文献求助30
8秒前
8秒前
wanci应助xiaofan采纳,获得10
8秒前
9秒前
9秒前
9秒前
Cc发布了新的文献求助10
9秒前
Orange应助美丽寒凝采纳,获得10
10秒前
10秒前
大头驴发布了新的文献求助10
10秒前
ableyy发布了新的文献求助10
11秒前
高分求助中
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Effective Learning and Mental Wellbeing 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3974559
求助须知:如何正确求助?哪些是违规求助? 3518949
关于积分的说明 11196503
捐赠科研通 3255066
什么是DOI,文献DOI怎么找? 1797673
邀请新用户注册赠送积分活动 877076
科研通“疑难数据库(出版商)”最低求助积分说明 806130