The relationship between early atherosclerosis and endothelial dysfunction in type 1 diabetic patients as evidenced by measurement of carotid intima-media thickness and soluble CD146 levels: a cross sectional study

医学 内科学 血管病学 内皮功能障碍 糖尿病 内膜中层厚度 内分泌学 门诊部 肌酐 2型糖尿病 胃肠病学 甘油三酯 胆固醇 血脂谱 人体测量学 颈动脉
作者
Sema Çiftçi Doğanşen,Ayşen Helvacı,Mine Adaş,Suzan Deniz Onal
出处
期刊:Cardiovascular Diabetology [BioMed Central]
卷期号:12 (1) 被引量:20
标识
DOI:10.1186/1475-2840-12-153
摘要

Detection of early vascular changes prior to clinical manifestations of atherosclerosis, such as increased arterial carotid intima-media thickness (CIMT) and impaired endothelial function is of paramount importance for early identification of subjects at increased risk of accelerated atherosclerosis. The present study was designed to evaluate the relationship between early atherosclerosis and endothelial dysfunction in type 1 diabetic patients based on measurements of CIMT and soluble CD146 (sCD146) levels.Thirty-seven patients with type 1 diabetes, 14 males (37.8%) and 23 females (62.2%), of mean (SD) age 26.2 (4.1) years admitted to the outpatient diabetes clinic at Okmeydani Training and Research Hospital, Istanbul, between January 2008 and December 2012, and 37 healthy controls, 16 males (43.2%) and 21 females (56.8%), of mean (SD) age 25.8 (3.1) years, selected from relatives of patients, were included. Anthropometric measures; fasting plasma glucose; and serum HbA1c, total cholesterol, HDL-cholesterol, LDL-cholesterol, triglyceride and creatinine concentrations were compared, as were CIMT and serum sCD146.Mean (SD) sCD146 levels were significantly higher in patients than in controls (314.6 (141.9) ng/ml vs. 207.8 (34.5) ng/ml, p = 0.001), but mean (SD) CIMT did not differ (0.5 (0.1) mm vs. 0.4 (0.1) mm). ROC curves for sCD146 significantly differed in differentiating type 1 diabetics from healthy controls (p = 0.0047) with a significantly higher percentage of patients than controls having sCD146 levels >260 ng/ml (21/37 (56.8%) vs. 2/37 (5.4%), p = 0.00011).Our findings emphasize that sCD146 levels may be a more sensitive marker than CIMT for earlier identification of type 1 diabetic patients at high risk for atherosclerosis.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
吃吃发布了新的文献求助10
1秒前
aaefv完成签到,获得积分10
2秒前
大菊发布了新的文献求助10
4秒前
5秒前
RNNNLL完成签到,获得积分10
5秒前
搜集达人应助大力的诗蕾采纳,获得10
7秒前
9秒前
lanyun00123关注了科研通微信公众号
11秒前
秋不落棠发布了新的文献求助10
12秒前
12秒前
13秒前
自然友菱完成签到,获得积分10
14秒前
领导范儿应助xkyasc采纳,获得10
15秒前
在水一方应助luo采纳,获得10
15秒前
16秒前
20011013完成签到 ,获得积分10
16秒前
iNk应助微微采纳,获得10
16秒前
17秒前
17秒前
飞乐扣完成签到 ,获得积分10
18秒前
粗暴的君浩完成签到,获得积分10
18秒前
在水一方应助emm采纳,获得10
19秒前
22秒前
高文琴完成签到,获得积分10
22秒前
量子星尘发布了新的文献求助10
22秒前
monoklatt发布了新的文献求助10
23秒前
查查完成签到,获得积分10
23秒前
24秒前
必中发布了新的文献求助10
24秒前
所所应助jiang采纳,获得10
25秒前
李健应助HelloKun采纳,获得10
26秒前
晚风完成签到,获得积分10
26秒前
26秒前
默默雅阳发布了新的文献求助10
27秒前
勤恳的不二完成签到,获得积分10
27秒前
FashionBoy应助狂野忆文采纳,获得10
28秒前
hx完成签到,获得积分10
28秒前
SciGPT应助狂野忆文采纳,获得10
28秒前
小马甲应助狂野忆文采纳,获得10
28秒前
单薄的夜南应助狂野忆文采纳,获得10
28秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Toward a Combinatorial Approach for the Prediction of IgG Half-Life and Clearance 500
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3969940
求助须知:如何正确求助?哪些是违规求助? 3514642
关于积分的说明 11175298
捐赠科研通 3249947
什么是DOI,文献DOI怎么找? 1795178
邀请新用户注册赠送积分活动 875617
科研通“疑难数据库(出版商)”最低求助积分说明 804891