Polysilsesquioxane Nanoparticles for Targeted Platin‐Based Cancer Chemotherapy by Triggered Release

Angewandte Chemie International EditionVolume 50, Issue 44 p. 10330-10334 Communication Polysilsesquioxane Nanoparticles for Targeted Platin-Based Cancer Chemotherapy by Triggered Release† Joseph Della Rocca, Joseph Della Rocca Department of Chemistry, CB#3290, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599 (USA) http://www.chem.unc.edu/people/faculty/linw/wlindex.htmlSearch for more papers by this authorRachel C. Huxford, Rachel C. Huxford Department of Chemistry, CB#3290, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599 (USA) http://www.chem.unc.edu/people/faculty/linw/wlindex.htmlSearch for more papers by this authorErica Comstock-Duggan, Erica Comstock-Duggan Department of Chemistry, CB#3290, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599 (USA) http://www.chem.unc.edu/people/faculty/linw/wlindex.htmlSearch for more papers by this authorProf. Wenbin Lin, Corresponding Author Prof. Wenbin Lin [email protected] Department of Chemistry, CB#3290, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599 (USA) http://www.chem.unc.edu/people/faculty/linw/wlindex.htmlDepartment of Chemistry, CB#3290, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599 (USA) http://www.chem.unc.edu/people/faculty/linw/wlindex.htmlSearch for more papers by this author Joseph Della Rocca, Joseph Della Rocca Department of Chemistry, CB#3290, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599 (USA) http://www.chem.unc.edu/people/faculty/linw/wlindex.htmlSearch for more papers by this authorRachel C. Huxford, Rachel C. Huxford Department of Chemistry, CB#3290, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599 (USA) http://www.chem.unc.edu/people/faculty/linw/wlindex.htmlSearch for more papers by this authorErica Comstock-Duggan, Erica Comstock-Duggan Department of Chemistry, CB#3290, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599 (USA) http://www.chem.unc.edu/people/faculty/linw/wlindex.htmlSearch for more papers by this authorProf. Wenbin Lin, Corresponding Author Prof. Wenbin Lin [email protected] Department of Chemistry, CB#3290, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599 (USA) http://www.chem.unc.edu/people/faculty/linw/wlindex.htmlDepartment of Chemistry, CB#3290, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599 (USA) http://www.chem.unc.edu/people/faculty/linw/wlindex.htmlSearch for more papers by this author First published: 14 September 2011 https://doi.org/10.1002/anie.201104510Citations: 71 † We acknowledge financial support from NIH (U01-CA151455 and U54-119343). We would like to thank Kathryn deKrafft, Asif Khan, and Honorio Lara for experimental help and acknowledge technical support from the UNC Animal Studies Core. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Graphical Abstract Trigger happy: Polysilsesquioxane (PSQ) nanoparticles that contain a PtIV-based active agent (1; see picture) can be used for the triggered delivery of chemotherapeutics. The cytotoxicity of 1 was superior to that of oxaliplatin against four cancer cell lines in vitro, and targeting further enhanced the cytotoxicity. PEGylated and anisamide-targeted 1 showed drastically superior efficacy to oxaliplatin in inhibiting tumor growth. Supporting Information Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Filename Description anie_201104510_sm_miscellaneous_information.pdf1.7 MB miscellaneous_information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. References 1B. Rosenberg, L. VanCamp, T. Krigas, Nature 1965, 205, 698. 10.1038/205698a0 CASPubMedWeb of Science®Google Scholar 2 2aY. Jung, S. J. 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