Irritability in Youth: An Update

Chronic or severe irritability is one of the most common reasons children present for mental health services, yet there is a notable gap between the public health impact of irritability and our understanding of its pathophysiology and how it mediates risk for psychopathology. Research advances in these areas are vital to identifying novel targets and optimal timing for intervention and, ultimately, for improving long-term outcomes for children with chronic irritability and their families.