奥拉帕尼
医学
前列腺癌
PARP抑制剂
聚合酶
肿瘤科
癌症研究
前列腺
聚ADP核糖聚合酶
DNA修复
癌症
内科学
DNA
生物
遗传学
作者
Joaquı́n Mateo,Suzanne Carreira,Shahneen Sandhu,Susana Miranda,Helen Mossop,Raquel Pérez-López,Daniel Nava Rodrigues,Dan R. Robinson,Aurelius Omlin,Nina Tunariu,Gunther Boysen,Núria Porta,Penny Flohr,Alexa Gillman,Ines Figueiredo,Claire Paulding,George Seed,Suneil Jain,Christy Ralph,Andrew Protheroe
标识
DOI：10.1056/nejmoa1506859
摘要
Prostate cancer is a heterogeneous disease, but current treatments are not based on molecular stratification. We hypothesized that metastatic, castration-resistant prostate cancers with DNA-repair defects would respond to poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP) inhibition with olaparib.
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(2025-6-4)
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