Cytological characteristics and application of MIN6 cell line

MIN6 cell line is established from insulinomas obtained by targeted expression of the simian virus 40 T antigen in transgenic non-obese diabetic mice. The endocrine function of MIN6 cells is similar to pancreatic tissue, which makes it an ideal model in researching the function of islet cells. The MIN6 cell line is used in pancreatic secretion in recent years, and also in finding stimulus signal to β cells. MIN6 cell line is used to study the pathogenesis of type 1 diabetes as well as the effects of oxidative stress, autophagy and free fatty acids on the pathogenesis of type 2 diabetes. At the same time, it can be used to discuss the mechanism in reject reaction after pancreas transplantation. Key words: MIN6; Diabetes mellitus; Cytological characteristics; Autophagy