已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Zoledronate for the Prevention of Bone Loss in Women Discontinuing Denosumab Treatment. A Prospective 2-Year Clinical Trial

德诺苏马布 医学 骨重建 N-末端末端肽 骨矿物 泌尿科 骨质疏松症 骨量减少 股骨颈 临床终点 骨吸收 随机对照试验 内科学 前胶原肽酶 骨钙素 化学 生物化学 碱性磷酸酶
作者
Athanasios D. Anastasilakis,Socrates E. Papapoulos,Stergios A. Pοlyzos,Natasha M. Appelman‐Dijkstra,Polyzois Makras
出处
期刊:Journal of Bone and Mineral Research [Oxford University Press]
卷期号:34 (12): 2220-2228 被引量:129
标识
DOI:10.1002/jbmr.3853
摘要

ABSTRACT Cessation of denosumab treatment is associated with increases in bone turnover above baseline values and rapid bone loss. We investigated the efficacy of zoledronate to prevent this bone loss in women with postmenopausal osteoporosis who were treated with denosumab (mean duration 2.2 years) and discontinued treatment after achieving osteopenia. Women were randomized to receive a single 5-mg infusion of zoledronate (ZOL) (n = 27) or two additional 60-mg injections of denosumab (Dmab) (n = 30). Both groups were followed for a total period of 24 months. At 24 months lumbar spine–bone mineral density (LS-BMD) was not different from baseline in the ZOL group, but decreased in the Dmab group by (mean ± SD) 4.82% ± 0.7% (p < 0.001) from the 12-month value; the difference in BMD changes between the two groups, the primary endpoint of the study, was statistically significant (p = 0.025). Results of femoral neck (FN)-BMD changes were similar. ZOL infusion was followed by small but significant increases in serum procollagen type 1 N-terminal propeptide (P1NP) and C-terminal telopeptide of type 1 collagen (CTX) during the first year and stabilization thereafter. In the Dmab group, bone turnover marker values did not change during the first 12 months but increased significantly at 15 months and in the majority of women these remained elevated at 24 months. Neither baseline nor 12-month bone turnover marker values were associated with BMD changes in either group of women. In the Dmab group, three patients sustained vertebral fractures (two patients multiple clinical, one patient morphometric) whereas one patient in the ZOL group sustained clinical vertebral fractures 12 months after the infusion. In conclusion, a single intravenous infusion of ZOL given 6 months after the last Dmab injection prevents bone loss for at least 2 years independently of the rate of bone turnover. Follow-up is recommended, because in a few patients ZOL treatment might not have the expected effect at 2 years. © 2019 American Society for Bone and Mineral Research.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
一方通行完成签到 ,获得积分10
3秒前
重景完成签到 ,获得积分10
4秒前
5秒前
量子星尘发布了新的文献求助10
5秒前
红毛兔完成签到 ,获得积分10
5秒前
科研通AI5应助开心的中心采纳,获得10
6秒前
6秒前
高大凌寒发布了新的文献求助210
8秒前
娜娜发布了新的文献求助10
9秒前
子翱完成签到 ,获得积分10
10秒前
13秒前
啦啦啦啦完成签到,获得积分10
13秒前
无辜的百川关注了科研通微信公众号
14秒前
15秒前
17秒前
王琴发布了新的文献求助10
20秒前
小蘑菇应助坛子采纳,获得10
23秒前
Re完成签到 ,获得积分10
23秒前
花陵完成签到 ,获得积分10
29秒前
33秒前
直率若翠完成签到 ,获得积分10
33秒前
nana完成签到,获得积分10
34秒前
34秒前
直率若翠关注了科研通微信公众号
37秒前
量子星尘发布了新的文献求助10
38秒前
38秒前
假装学霸完成签到 ,获得积分10
38秒前
39秒前
小摩尔完成签到 ,获得积分10
39秒前
39秒前
真实的馒头完成签到,获得积分10
40秒前
儒雅冰岚完成签到,获得积分20
41秒前
41秒前
水杯不离手完成签到 ,获得积分10
42秒前
dachengzi完成签到,获得积分10
42秒前
yyyyyyyyyyyiiii完成签到 ,获得积分10
42秒前
44秒前
JamesPei应助开心的中心采纳,获得10
45秒前
48秒前
科研通AI5应助研友_VZGvVn采纳,获得10
50秒前
高分求助中
Production Logging: Theoretical and Interpretive Elements 2700
Neuromuscular and Electrodiagnostic Medicine Board Review 1000
Statistical Methods for the Social Sciences, Global Edition, 6th edition 600
こんなに痛いのにどうして「なんでもない」と医者にいわれてしまうのでしょうか 510
ALUMINUM STANDARDS AND DATA 500
Walter Gilbert: Selected Works 500
An Annotated Checklist of Dinosaur Species by Continent 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3666277
求助须知:如何正确求助?哪些是违规求助? 3225351
关于积分的说明 9762566
捐赠科研通 2935243
什么是DOI,文献DOI怎么找? 1607513
邀请新用户注册赠送积分活动 759242
科研通“疑难数据库(出版商)”最低求助积分说明 735185