细胞标志蛋白
医学
尼福林
突触素
足细胞
内科学
糖尿病
泌尿系统
肌酐
胱抑素C
2型糖尿病
肾脏疾病
肾
2型糖尿病
泌尿科
内分泌学
蛋白尿
作者
Ligia Petrică,Agneta-Maria Pusztai,Mihaela Vlad,Adrian Vlad,Florica Gădălean,Victor Dumitraşcu,Daliborca Vlad,Silvia Velciov,Cristina Gluhovschi,Flaviu Bob,Sorin Ursoniu,Maxim Petrica,Petru Matusz,Octavian Creţu,Daniela Radu,Oana Milaş,Alina Secara,Anca Simulescu,Roxana Popescu,Dragoș Cătălin Jianu
标识
DOI:10.1080/07435800.2019.1690505
摘要
Background: The association of vascular remodeling in the kidney and the brain with a particular microRNAs (miRNA) profile is not well studied.Methods: Seventy-six patients with Type 2 diabetes and 11 healthy subjects were assessed concerning urine albumin: creatinine ratio (UACR), biomarkers of podocyte injury and of proximal tubule (PT) dysfunction. MiRNA were quantified in blood and urine by a real-time PCR System. Cerebrovascular ultrasound measurements were performed in the carotid and middle cerebral arteries.Results: MiRNA21 and miRNA124 correlated positively with nephrin, podocalyxin, synaptopodin, urinary N-acetyl-D-glucosaminidase (NAG), urinary kidney-injury molecule-1 (KIM-1), UACR, and negatively with eGFR; miRNA125a, 126, 146a, 192 correlated negatively with nephrin, podocalyxin, synaptopodin, urinary NAG, urinary KIM-1, UACR, and directly with eGFR. Plasma miRNA-21 and miRNA192 correlated directly with cerebral hemodynamics parameters of atherosclerosis and arteriosclerosis. MiRNA-124, 125a, 126, 146a showed negative correlations with the same parameters.Conclusions: In Type 2 diabetes patients there is an association of vascular remodeling in the brain and the kidney with a specific miRNAs pattern. Cerebrovascular changes occur even in normoalbuminuric patients, with ‘high-to-normal’ levels of podocyte injury and PT dysfunction biomarkers. These phenomena may be explained by the variability of miRNA expression within the two organs in early DKD.
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