剧目
怀孕
多发性硬化
自身免疫
生物
免疫系统
T细胞
免疫学
疾病
细胞
克隆(Java方法)
自身免疫性疾病
遗传学
医学
抗体
内科学
基因
物理
声学
作者
Caren Ramien,Erik Yusko,Jan Broder Engler,Stefanie Gamradt,Kostas Patas,Nils Schweingruber,Anne Willing,Sina Cathérine Rosenkranz,Anke Diemert,Anja Harrison,Marissa Vignali,Catherine Sanders,Harlan Robins,Eva Tolosa,Christoph Heesen,Petra C. Arck,Alexander Scheffold,Kenneth K. Chan,Ryan Emerson,Manuel A. Friese,Stefan M. Gold
出处
期刊:Cell Reports
[Elsevier]
日期:2019-10-01
卷期号:29 (4): 810-815.e4
被引量:16
标识
DOI:10.1016/j.celrep.2019.09.025
摘要
Identifying T cell clones associated with human autoimmunity has remained challenging. Intriguingly, many autoimmune diseases, including multiple sclerosis (MS), show strongly diminished activity during pregnancy, providing a unique research paradigm to explore dynamics of immune repertoire changes during active and inactive disease. Here, we characterize immunomodulation at the single-clone level by sequencing the T cell repertoire in healthy women and female MS patients over the course of pregnancy. Clonality is significantly reduced from the first to third trimester in MS patients, indicating that the T cell repertoire becomes less dominated by expanded clones. However, only a few T cell clones are substantially modulated during pregnancy in each patient. Moreover, relapse-associated T cell clones identified in an individual patient contract during pregnancy and expand during a postpartum relapse. Our data provide evidence that profiling the T cell repertoire during pregnancy could serve as a tool to discover and track “private” T cell clones associated with disease activity in autoimmunity.
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