[The clinical characteristics, diagnosis and treatment of patients with gout in China].

Objective: To investigate the demographic characteristics, clinical features, diagnosis and treatment of patients with gout in China. Methods: Clinical data of 6 814 patients with gout from 100 hospitals in 27 provinces, municipalities or autonomous regions in China were collected and analyzed. Results: (1) The ratio of male to female in patients with gout was 14.7∶1. The mean age of onset was (48.8±15.1) years old. Mean serum urate level was (526.7±132.3) μmol/L. Patients' education background was of U-shaped distribution; (2) Hypertension was the most common comorbidity [15.8%(1 079/6 814)], then overweight or obesity [51.9%(3 536/6 814)]; (3) Alcohol and high-purine food intake were dominant triggering factors in men. The diagnosis of gout was made after onset in majority of patients with cardinal symptom arthralgia. Most patients had the disease less than 5 years, and the longer the course, the more flares in the previous year of entry; (4) Febuxostat was the mostly used urate-lowering medication. 20.7%(1 412/6 814), 10.8%(739/6 814) and 3.9%(265/6 814) of patients were followed up in 4 weeks, 12 weeks and 24 weeks after registration, and 18.9%(267/1 412), 29.1%(215/739) and 38.1%(101/265) of them reached the control target of serum urate levels, respectively. After treatment, patients' liver function was not affected, but serum creatinine levels decreased significantly. Conclusions: The proportion of gout patients who reach target serum urate level is very low. Further steps including education and survey need to be carried on.目的： 了解目前我国痛风患者的临床特点和治疗现状。 方法： 收集2013年9月至2016年2月在中国国家风湿病数据中心登记注册的全国27个省、市、自治区100家医院的6 814例痛风患者的临床资料，分析其临床特点及治疗现状。 结果： （1）痛风患者男∶女为14.7∶1，发病年龄（48.8±15.1）岁，血尿酸水平（526.7±132.3）μmol/L，受教育程度呈U形分布；（2）痛风患者的合并症累及系统广泛，其中合并高血压者最多占15.8%（1 079/6 814），51.9%（3 536/6 814）的患者体重指数（BMI）超标；（3）痛风发作的主要诱因男女略有不同，饮酒和高嘌呤饮食仍是男性痛风发作的主要诱因；痛风患者初诊的正确诊断率较高[85.7%（5 837/6 814）]，就诊以关节痛为主要症状，病程5年内的患者居多，病程越长，既往一年痛风急性发作次数越多；（4）痛风患者降尿酸药物以非布司他为主，治疗4周、12周和24周的随访率分别为20.7%（1 412/6 814）、10.8%（739/6 814）和3.9%（265/6 814），血尿酸水平达标率分别为18.9%（267/1 412）、29.1%（215/739）和38.1%（101/265），治疗前后肝功能无明显变化，但血肌酐明显下降。 结论： 目前我国痛风患者的随访率和血尿酸水平达标率仍很低，因此需要加强痛风患者的长期规范化管理。.