光老化
衰老
癌变
炎症
生物
细胞生物学
表型
皮肤老化
皮肤癌
免疫学
癌症
癌症研究
医学
皮肤病科
遗传学
基因
作者
Eleni Fitsiou,Tanya Pulido,Judith Campisi,Fatouma Alimirah,Marco Demaria
标识
DOI:10.1016/j.jid.2020.09.031
摘要
Chronic exposure to UVR is known to disrupt tissue homeostasis, accelerate the onset of age-related phenotypes, and increase the risk for skin cancer-a phenomenon defined as photoaging. In this paper, we review the current knowledge on how UV exposure causes cells to prematurely enter cellular senescence. We describe the mechanisms contributing to the accumulation of senescent cells in the skin and how the persistence of cellular senescence can promote impaired regenerative capacity, chronic inflammation, and tumorigenesis associated with photoaging. We conclude by highlighting the potential of senolytic drugs in delaying the onset and progression of age-associated phenotypes in the skin.
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