超分子化学
层级组织
机制(生物学)
结晶
自组织
生物分子
材料科学
纳米技术
结晶学
计算机科学
化学
晶体结构
物理
人工智能
经济
有机化学
管理
量子力学
作者
Chengqian Yuan,Wei Ji,Ruirui Xing,Junbai Li,Ehud Gazit,Xuehai Yan
标识
DOI:10.1038/s41570-019-0129-8
摘要
Hierarchical self-assembly and crystallization with long-range ordered spatial arrangement is ubiquitous in nature and plays an essential role in the regulation of structures and biological functions. Inspired by the multiscale hierarchical structures in biology, tremendous efforts have been devoted to the understanding of hierarchical self-assembly and crystallization of biomolecules such as peptides and amino acids. Understanding the fundamental mechanisms underlying the construction and organization of multiscale architectures is crucial for the design and fabrication of complex functional systems with long-range alignment of molecules. This Review summarizes the typical examples for hierarchically oriented organization of peptide self-assembly and discusses the thermodynamic and kinetic mechanisms that are responsible for this specific hierarchical organization. Most importantly, we propose the concept of hierarchically oriented organization for self-assembling peptide crystals, distinct from the traditional growth mechanism of supramolecular polymerization and crystallization based on the Ostwald ripening rule. Finally, we assess critical challenges and highlight future directions towards the mechanistic understanding and versatile application of the hierarchically oriented organization mechanism. Hierarchical self-assembly and crystallization is ubiquitous in nature and is of key importance for creation of complex superstructures. Herein, Yuan and co-workers propose that hierarchically oriented organization guides the formation of such complex systems, especially in supramolecular peptide crystals.
科研通智能强力驱动
Strongly Powered by AbleSci AI