医学
全身炎症
肺动脉高压
内皮功能障碍
全身性疾病
肺动脉
心脏病学
冠状动脉疾病
心力衰竭
疾病
内科学
炎症
病理
血管疾病
作者
K. Kearney,Eugene Kotlyar,Edmund Lau
标识
DOI:10.1016/j.ccm.2020.11.001
摘要
Pulmonary arterial hypertension (PAH) is a disease of progressive pulmonary vascular remodeling due to abnormal proliferation of pulmonary vascular endothelial and smooth muscle cells and endothelial dysfunction. PAH is a multisystem disease with systemic manifestations and complications. This article covers the chronic heart failure syndrome, including the systemic consequences of right ventricle-pulmonary artery uncoupling and neurohormonal activation, skeletal and respiratory muscle effects, systemic endothelial dysfunction and coronary artery disease, systemic inflammation and infection, endocrine and metabolic changes, the liver and gut axis, sleep, neurologic complications, and skin and iron metabolic changes.
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