纳米医学
纳米技术
癌细胞
体内
细胞
材料科学
膜
癌症
细胞膜
药物输送
癌症治疗
生物物理学
纳米颗粒
化学
医学
生物
生物化学
生物技术
内科学
作者
Jingyi Zhu,Cansu Sevencan,Mingkang Zhang,Reece McCoy,Xianguang Ding,Jing‐Jie Ye,Jianping Xie,Katsuhiko Ariga,Jun Feng,Boon‐Huat Bay,David Tai Leong
出处
期刊:ACS Nano
[American Chemical Society]
日期:2020-02-12
卷期号:14 (3): 3259-3271
被引量:78
标识
DOI:10.1021/acsnano.9b08798
摘要
The cancer cell membrane contains an arsenal of highly specific homotypic moieties that can be used to recognize its own kind. These cell membranes are often used to coat spherical nanoparticles to enhance nanomedicines’ targeting specificities and uptakes. A sphere, however, has only a point contact with a surface at any given time. It is shown here that, by retaining a flatter morphology of the cracked cell membrane through stiffening with in situ synthesized gold nanomaterials, an increased area of interaction could be maintained and hence improve upon the in vitro and in vivo homotypic targeting capabilities between cancer cell types. This enhancement is especially important in vivo as any nanomedicine with targeting moieties probably has a single pass at interacting with the target cell before subsequent system clearance. Possible future clinical applications may involve the usage of a patient’s autologous tumor biopsy tissues, which are very limited in supply, and therefore ensuring that we capitalize on the entire collective surface area of the cancer cell membrane available becomes an important consideration in the design and delivery our cell membrane-derived nanomedicines.
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